4
disease states live
2,385
scoring rules
991
pharmacist-reviewed passages
0
rankings written by AI

Deterministic by construction.

“Keep patients on the fewest number of meds to get the best end results.”

Pharmacist-verified rules score every recommendation. Dr. EASE, our AI assistant, explains the ranking and answers follow-ups. The AI never invents the verdict.

Explore a scored caseSee how it works
trace / Type 2 Diabetesreproducible
boost-Semaglutide-165CV benefit; SUSTAIN-6 MACE reduction
boost-Semaglutide-166Weight benefit; very high weight loss efficacy; ADA preferred for weight management
boost-Semaglutide-169Renal benefit; demonstrated CKD progression reduction (FLOW trial)
Rules that fired on the winning option, Start Semaglutide (Ozempic), in a published proof case: Age 62, A1C 8.4%, ASCVD, Hypertension, Chronic Kidney Disease. Each row carries the id the engine reported.
output
  1. 1Start Semaglutide (Ozempic)
  2. 2Start Empagliflozin (Jardiance)
  3. 3Start Metformin SA

What's new

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  • Production-ready

    Epic on FHIR

    Health systems on Epic can enable DisEASE.

    Epic is a trademark of Epic Systems Corporation. DisEASE is an independent product of DisEASE LLC and is not endorsed, certified, or sponsored by Epic.

    Integration details

  • Beta, by request

    MCP connector

    Author and test DisEASE rules from your own AI agent through the Model Context Protocol.

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Clinical Proof Reviewno sign-in

Inspect the engine's work, case by case

Twelve complete workups across Type 2 Diabetes, Hypertension, and Heart Failure (HFrEF and HFpEF), scored by DisEASE's production rule engine in August 2026. Every ranking, safety alert, fired rule, and citation comes straight from the engine. Only the proprietary rule weights are withheld.

  1. 01Ranked options with clinical-fit scores for every candidate drug
  2. 02Deny, caution, and safety alerts tied to the labs, vitals, and medications that triggered them
  3. 03Recommendations and safety alerts cited to FDA labeling, clinical guidelines, and trial evidence

Open the Proof Review

Synthetic patient data, no PHI. Built on clinician-reviewed rules and sources. Not a substitute for clinical judgment; not validated for patient care.

Disease-state modules

4 verifiedView all
verifiedT2DType 2 DiabetesDeterministic medication rankings from pharmacist-verified rules, weighted by A1C target, comorbidities, insurance coverage, and current therapy. Grounded in the ADA 2026 Standards of Care.599 rulesverifiedHTNHypertensionGuideline-based antihypertensive therapy recommendations with blood pressure target management and compelling indication detection. Grounded in the AHA/ACC 2025 Hypertension Guideline.718 rulesverifiedHFrEFHeart Failure (Reduced EF)Four-pillar GDMT optimization for heart failure with reduced ejection fraction. Grounded in the 2022 AHA/ACC/HFSA HF Guideline.504 rulesverifiedHFpEFHeart Failure (Preserved EF)Comorbidity-driven therapy for heart failure with preserved ejection fraction, built on a pharmacist-audited, HFpEF-specific rule set. Grounded in the 2022 AHA/ACC/HFSA HF Guideline.564 rules

Common questions

Written for clinicians who have been sold software before.

DisEASE is designed to improve EQM scores, a key driver for reimbursement rates. It is built to raise the floor for all providers and to help postpone costly specialist referrals by giving primary care teams the confidence to manage complex pharmacotherapy.

It is designed to. Our dynamic note feature drafts an assessment and plan for the provider to review and edit, in approximately 15 seconds.

DisEASE's standard workup is designed so PHI never enters the system: you enter de-identified clinical data only. In EHR-launched sessions, chart data pre-fills the workup for the duration of the session and is not retained after the session ends. Our infrastructure is built to HIPAA security standards, all data transmission is encrypted, and we never store patient-identifying information.

No. DisEASE is stand-alone and fully usable without EHR integration. For Epic organizations, DisEASE is also available as a provider-facing SMART on FHIR app: clinicians launch it from the patient chart, and the workup pre-fills from chart data. See our Epic on FHIR documentation for details.

Every recommendation ships with a per-rule trace log: which pharmacist-verified rules fired, what evidence they cite, and how they combined into the final ranking. Same inputs always produce the same recommendation. DisEASE is built by practicing clinicians and pharmacists, grounded in current evidence-based guidelines, and continuously improved through provider feedback.

No. Drug rankings come from a deterministic scoring engine verified by clinical pharmacists, so the same patient inputs always produce the same scores. Dr. EASE, our AI assistant, explains the ranking, answers questions, and retrieves FDA labeling or trial data. It cannot rewrite the score or fabricate a recommendation.

DisEASE currently supports Type 2 Diabetes, Hypertension, and Heart Failure (both reduced and preserved ejection fraction).

No. DisEASE is designed for adult patients age 18 and older and should not be used to guide pediatric treatment. Age-specific pediatric factors are not included in the scoring engine.

Only the clinical data fields provided in the form (age, labs, comorbidities, allergies, current therapies, and other clinical signals). Do not enter anything that identifies the patient, such as a name, date of birth or record number.

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See a scored case before you decide anything

Twelve complete workups, every rule that fired, and the source behind each one. No sign-in.

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